blogspot.comCompared with mouse thymocytes, mouse ES cells include higher ranges of total genomic H3K4me3 and have greater H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In settlement with this, global decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven As well as, there are dynamic modifications in H3K4me3 profiles at specific sets of genes during ES cell differentiation.

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