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This family contains only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, in addition to histone, plenty of non-histone proteins, lawyer together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and parts of the TATA binding protein (TBP) advanced, TBP-associated elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (goal lysine is bold), can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of these substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a basic mannequin for dynamic lysine methylation of both histone and non-histone proteins.

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